Diarrhea in Dogs From Prednisone

Cuteness may earn compensation through affiliate links in this story.
Diarrhea in Dogs From Prednisone
Image Credit: damedeeso/iStock/GettyImages

Your veterinarian might prescribe the corticosteroid prednisone for a variety of canine ailments. While she might warn you that your dog will drink more water and urinate more frequently while on the drug, that's not prednisone's only side effect. The medication can cause diarrhea, but that side effect is more common in dogs receiving prednisone long term.


Video of the Day

Reasons for Prescribing

A synthetic corticosteroid, prednisone is generally prescribed for its anti-inflammatory properties. This drug is available in tablet and injectable form. Your vet may prescribe prednisone if your dog is diagnosed with:


  • allergies -- for itch relief
  • joint pain
  • hypercalcemia -- to reduce blood calcium levels
  • cancer
  • shock
  • or disorders of the central nervous system.

Your dog may also receive prednisone if his immune system is out of whack. Large doses of the medication cause immune system suppression.



Prednisolone is a very similar medication, and in most instances -- especially in dogs -- the use of the two are interchangeable.

Side Effects

Besides diarrhea and increased drinking and urinating, prednisone side effects include:

  • panting or vomiting
  • lethargy or behavioral changes
  • delayed wound healing
  • skin thinning
  • and poor coat quality.


When administered long term, dogs may develop diabetes mellitus or Cushing's disease. Young dogs may suffer from impaired growth.

Call Your Vet

If your dog develops diarrhea while on this medication, call your vet. Try to obtain a fecal sample, if necessary. Your vet may reduce the dosage or switch your dog to another medication. Make sure it is the prednisone that's causing loose stools. If you've changed your dog's food, or if he got into the garbage or otherwise ate something inappropriate, the prednisone may not be the cause of the diarrhea.

Always check with your veterinarian before changing your pet’s diet, medication, or physical activity routines. This information is not a substitute for a vet’s opinion.