Side Effects of Cefpodoxime Proxetil for Dogs

By Jane Meggitt

Cefpodoxime proxetil, marketed under the brand name Simplicef, is an antibiotic strictly for use in dogs and cats. Most canines tolerate the drug well, but a small number of dogs taking the drug might experience side effects. These are primarily gastrointestinal in nature. If you notice any side effects while your dog receives this drug, call your vet immediately.

Cefpodoxime Proxetil

If your dog is diagnosed with a skin infection, your vet might prescribe cefpodoxime proxetil for treatment. That's especially true if the infection results from E. coli, staphylococcus, Proteus mirabilis or Pasteurella multocida bacteria. Your vet also might prescribe it for treating respiratory, bladder and bone infections, along with infections occurring in abscesses or wounds. While the drug is similar to penicillin regarding bacteria eradication, it's more effective than the older medication and kills a larger range of bacteria.

Side Effects

Common side effects include vomiting, appetite loss and diarrhea. Rarely, a dog might experience a rash or hypersalivate while on the drug. Some canines become extremely excitable and might exhibit an increased respiration rate. A dog might bruise easily or experience jaundice, a yellowing of the eye whites and gums. Some dogs receiving cefpodoxime proxetil might erroneously test positive on a direct Coombs test, which detects anemia.

Cefpodoxime Proxetil Overdose

You should give only the amount of cefpodoxime proxetil tablets directed by your vet. If your dog receives an accidental overdose, call your vet but don't panic. Safety studies indicate that the drug was well-tolerated in dogs given 10 times the maximum dose for up to 13 weeks, and 28 days in puppies between the ages of 2 and 3 weeks old when the study began.

Cefpodoxime Proxetil Contraindications

Pregnant or nursing dogs, or dogs you intend to breed, should not receive cefpodoxime proxetil. The breeding contraindication holds true for male and female canines. Cefpodoxime proxetil should not be administered to dogs with kidney disease or epilepsy. Let your vet know of any other medications or supplements your dogs receive. If he's on a blood thinner, cefpodoxime proxetil is contraindicated. Dogs with sensitivities to any penicillin products should not receive this medication. If your dog has ever experienced a reaction to a cephalosporin medication -- including cephalexin, cefprozil, cefazolin, cefa tabs or drops -- he should not receive cefpodoxime proxetil. Humans with penicillin allergies should avoid handling cefpodoxime proxetil. If that's impractical, always use gloves when handling or giving the medication to your dog.