Side Effects of Using Proin in Dogs

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Proin, the short name for phenylpropanolamine, often abbreviated as PPA, is a common drug for dogs prescribed by a veterinarian. Even though quite effective, Proin may cause side effects in dogs.


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Proin is a drug used to treat urinary incontinence in dogs. It mainly works by effectively strengthening the sphincter tone of the urethra that often weakens as the dog ages.


According to, Proin was used some years ago as a medication for humans but was pulled off the market because it was suspected of increasing the chances of stroke and cerebral hemorrhage. Such side effects have not been observed in dogs.



Because Proin stimulates the release of the stress hormone norepinephrine its use may elicit a ''flight or flight response." Dogs using Proin may be susceptible to side effects including increased heart rate, nervousness, restlessness, increased blood pressure and loss of appetite.


In some cases, dogs may develop weakness, pale gums, seizures and difficulty urinating. Report any side effects to the veterinarian.



Proin should be used with caution in dogs affected by overactive thyroid, diabetes, glaucoma, high blood pressure and heart disease. The drug may interact with ephedrine, aspirin and tricyclic antidepressants.

Always check with your veterinarian before changing your pet’s diet, medication, or physical activity routines. This information is not a substitute for a vet’s opinion.