Temaril-P Side Effects in Dogs

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Temaril-P is a prescription medication that is intended for canine use. Temaril-P is used to provide relief for itchiness in dogs. It is also used to decrease inflammation that is often associated with canine skin conditions, including dermatitis, otititis, and eczema. Temaril-P is also often used to treat coughing in dogs, including kennel cough as well as bronchitis and coughs of nonspecific origin. It can be used in combination with other meds to treat bacterial infections too. There are various different side effects that are occasionally associated with use of Temaril-P.


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How does Temaril-P for dogs work?

Temaril-P tablets contain a combination of trimeprazine and prednisolone. These meds work synergistically to alleviate symptoms that occur as a result of an immune response, like itching and inflammation.


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Trimeprazine, an antihistamine, counteracts histamines. These chemicals are released by the immune system during an allergic reaction to remove allergens from the body and can produce a variety of unpleasant symptoms. Trimeprazine provides relief of itching, inflammation, and coughing that occur when histamines are produced during an allergic reaction. Sedation is another effect of trimeprazine.


Prednisolone, a corticosteroid, is a type of steroid that mimics cortisol, a naturally occurring hormone. Similar to antihistamines, corticosteroids stop the immune system from producing chemicals that trigger inflammation. By reducing inflammation, it also helps to relieve pain by relieving pressure on surrounding nerves.


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Temaril-P for dogs side effects

Side effects of Temaril-P in dogs can be serious. If symptoms are particularly problematic and do not subside, veterinary attention must be sought immediately. Some of the most common symptoms include:


  • Upset stomach
  • Diarrhea
  • Vomiting
  • Excessive food ingestion
  • Extreme thirst
  • Weight gain
  • Dry and dull coat
  • Panting
  • Frequent urination
  • Viciousness
  • Aggressive behavior
  • Lethargy
  • Depression
  • Muscle wasting
  • Hypotension (low blood pressure)

Temaril-P drug interactions

Temaril-P can adversely interact with certain other medications and supplements. Tell your veterinarian about any medications, vitamins, or supplements your pet is taking. Medications that tend to interact negatively with Temaril-P include but are not limited to:



  • Angiotensin-converting-enzyme (ACE) inhibitors
  • Amphotericin B
  • Antacids
  • Antidiarrheals
  • Anticholinesterases
  • Aspirin
  • Cisapride
  • Central nervous system depressant agents
  • Cyclophosphamide
  • Cyclosporine
  • Digoxin
  • Potassium-depleting diuretics
  • Ephedrine
  • Estrogens
  • Insulin
  • Ketoconazole
  • Mitotane
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Paroxetine
  • Phenobarbital
  • Phenytoin
  • Rifampin
  • Vaccines


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Corticosteroid side effects

Temaril-P is a combination of a corticosteroid and antihistamine. There are various side effects that are often linked to use of corticosteroids, including loss of potassium, sodium retention, increased levels of SAP (serum alkaline phosphatase) and SGPT (gamma-glutamyl transpeptidase), diarrhea (sometimes bloody), throwing up, osteoporosis, weight loss, slow healing of wounds, Cushing's disease, suppression of adrenal cortical functions, increased liver enzymes, blood dyscrasias, and negative nitrogen balance. Dogs might also become more susceptible to bacterial invasion due to use of Temaril-P.


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Other possible Temaril-P side effects

Dogs might also experience extreme drowsiness and exhaustion from Temaril-P. The drowsiness should subside quickly. Urinary retention is a possible but highly rare side effect of Temaril-P. Dry mouth is another possible side effect of the medication. Should any of these side effects persist or get worse with time, veterinary attention must be received as soon as possible.

The bottom line

Temaril-P is a prescription corticosteroid and antihistamine used to treat various conditions in dogs, such as dermatitis, otitis, eczema, and bronchitis. It counteracts certain immune system responses that can be uncomfortable or even harmful, including coughing, inflammation, and itchiness. Tell your veterinarian about any other medications or supplements your dog is taking before starting Temaril-P, as it can cause adverse interactions. The medication can also produce several side effects, and it is important to monitor your dog closely and seek veterinary care if these effects are severe or persistent.


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